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PEDF is only highly expressed in undifferentiated human retinal cells, like Y79 retinoblastoma cells, but is either absent or down-regulated in their differentiated counterparts

They can extend from the inner corners of the eyes to the bridge and even the dorsum of the nose

doi: 10.3390/ijms24010340 24 ChenTYangCS

Reconstitution is the trade-off: you gain long-term stability before mixing, but once water is added, the clock starts

Getty Stock image of woman using a neti pot

Initial clinical failures, like that seen with VNP20009, have enlightened: a bacterial therapy for maximal efficacy should not be based on the removal of overall virulence, but on fine-tuned spatiotemporal control, provided by tools such as synthetic gene circuits (e.g., SLC and Cello)